AI-driven discovery and engineering of human-derived protein scaffolds for mRNA delivery nature.com

Researchers led by Dongmin Xun, Lanqing Li, Bolin An, Pheng Ann Heng and Chao Zhong developed DeepDelivery, an AI platform that screened human proteins for use in mRNA-delivery particles. Of 15 candidates tested, 12 helped form particles and deliver mRNA; several were TRIM-family proteins, and engineering TRIM25 domains improved its delivery performance.